Side effects of long-term use of 0.01% atropine eye drops include the occurrence of adverse reactions including photophobia, difficulty in seeing near, and changes in intraocular pressure. 1. photophobia: atropine acts on the pupillary sphincter to paralyze it, increasing the diameter of the pupil and the amount of light entering the eye, causing symptoms such as photophobia and glare, and the occurrence of these symptoms is positively correlated with the amount of atropine. 2. Difficulty in seeing: atropine can selectively block the innervation of cholinergic nerves to the ciliary muscle, resulting in temporary regulation of paralysis, and the long-term use of atropine eye drops may cause insufficient regulation, decrease in the amplitude of regulation, and difficulty in seeing. 3. Changes in intraocular pressure: After topical application of atropine eye drops, the pupil dilates and the iris recedes to the periphery, resulting in thickening of the iris root and relative narrowing of the atrial angle space, which may impede the outflow of atrial fluid and lead to an increase in intraocular pressure. If any of the above adverse reactions occur, consult your doctor promptly and take appropriate measures according to your doctor’s advice.