The causes of high alpha-fetoprotein and ferritin may be physiologic causes, liver diseases, liver cancer, etc. 1. Physiological reasons: if the alpha-fetoprotein and ferritin are only slightly elevated and the liver and kidney are normal in abdominal ultrasound and other examinations, they may be only physiologically elevated and have no clinical significance. 2. Liver disease: such as hepatitis B, cirrhosis and other liver diseases, may appear in alpha-fetoprotein and ferritin elevation, usually a transient increase. 3. Cancer: alpha-fetoprotein is mainly used as a serum marker for primary liver cancer, and alpha-fetoprotein will increase continuously and ferritin will also increase when suffering from liver cancer. There may be other reasons for high alpha-fetoprotein and ferritin, so it is recommended to go to the hospital in time to find out the cause of the disease and then target treatment.