Chest blockage and breath-holding at 3 or 4 a.m. may be caused by a variety of conditions, such as physiological factors, bradycardia, coronary artery disease, apnea hypopnea syndrome, etc., and should be selected according to the different conditions of general treatment, drugs, surgery and non-invasive positive airway pressure ventilation treatment. 1. Physiological factors: If you are mentally nervous before sleep or have nightmares during sleep, you will suddenly wake up with chest congestion and other discomforts, which will be relieved by relieving mental stress and improving living habits. 2. Bradycardia: if due to conduction block or sinus node lesions, caused by bradycardia, coupled with the elevation of vagal excitability during sleep at night, the heart rate will gradually slow down, if it can’t meet the body’s normal needs, the myocardial ischemia will appear in the chest blockage and breathlessness symptoms, after clarifying the cause of the disease, you can follow the instructions given by the doctor to give oral atropine, salbutamol orally, and if the condition is serious, it may require cardiac pacemaker implantation treatment. 3. Coronary artery disease: at night, the whole body sleeps with slow blood flow, the coagulation substances in the blood will gather to form blood vessels and block the blood vessels. Nitroglycerin can be given as prescribed by the doctor for sublingualization, oral aspirin enteric-coated tablets, atorvastatin, isosorbide mononitrate and other medications, and if the condition is serious, it may need to do a coronary angiography, and coronary artery stenting surgery is feasible when necessary. 4. Apnea and hypoventilation syndrome: abnormal sleep breathing rhythm or abnormal ventilation function at night, causing repeated intermittent hypoxia, resulting in chest blockage and breath holding, the treatment has general treatment, such as controlling weight, changing the sleeping position to side-lying, elevating the head of the bed, quitting smoking and alcohol, and for the more serious patients may need to carry out non-invasive positive airway pressure ventilation treatment. When there is a chest blockage at three or four o’clock in the morning breathlessness recurrence, it is recommended to go to the hospital in a timely manner, with the help of the doctor to clarify the cause of the disease, and according to the doctor’s instructions for targeted treatment.