Bilateral maxillary sinus mucosal thickening is mostly caused by acute and chronic maxillary sinusitis, which can be improved by taking antimicrobial drugs, decongestive drugs, anti-allergic drugs, glucocorticoid drugs and so on. 1. Acute maxillary sinusitis: ① cephalosporins, macrolides, penicillin and other antibacterial drugs can be taken for anti-infective treatment, such as cefixime, roxithromycin, amoxicillin, etc.; ② reduction of nasal congestion drugs, such as naphazoline hydrochloride, ephedrine, etc.; ③ anti-allergic drugs, such as cetirizine, loratadine, etc.. 2. Chronic maxillary sinusitis: nasal glucocorticoid medication can be used, such as beclomethasone propionate, budesonide spray and so on. These drugs need to be used on the basis of the doctor’s systematic examination to clarify the cause of the disease and the combination of symptoms. Some patients may experience side effects such as dizziness, drowsiness, gastrointestinal discomfort, etc., and should consult a doctor if they feel unwell.