Non-gonococcal urethritis generally refers to non-gonococcal urethritis, which is often caused by infection with mycoplasma and chlamydia, but may also be caused in some people by infection with trichomonas or spirochetes, mycobacteria, viruses, etc. Usually, non-gonococcal urethritis is caused by sexual transmission and most do not heal on their own. When infected with this disease, patients may experience symptoms such as frequent urination, urgency, painful urination, itching of the urethra, and a large amount of thin or white discharge. Without effective treatment, the condition may worsen and even lead to other complications, such as glansitis of the foreskin in men and vaginitis in women. Patients can be treated with oral medications under the guidance of a doctor, commonly macrolides such as azithromycin and roxithromycin, and tetracyclines such as minocycline and doxycycline. If the above drugs do not work well, quinolones such as moxifloxacin and levofloxacin, or cephalosporins such as cefdinir and cefixime can also be used. In daily life, patients should maintain good hygiene habits, wash their hands and change their underwear regularly. Drink more water to dilute the urine so that the germs can be eliminated. Avoid sexual intercourse during treatment to prevent cross-infection.