Higher acetylaminoglucosidase may indicate renal disease, drug toxicity and rejection reaction. 1. Renal diseases: a significant increase in urinary acetylaminoglucosidase suggests acute tubular necrosis, pyelonephritis, glomerulonephritis and so on. 2. Drug toxicity reaction: after the application of various nephrotoxic drugs in the clinic, the measurement of urinary acetylaminoglucosidase concentration will also be obviously high, and early renal damage can often be found. 3. Rejection reaction: after kidney transplantation, when acute rejection reaction occurs, urinary acetylaminoglucosidase will also be significantly elevated. It is recommended to go to the hospital for consultation, to clarify the cause of the disease and standardize the treatment under the guidance of professional physicians.