Both of them are macrolide antibiotics, the effect of both is relatively good, and there is no “which one is better”, need to be selected under the guidance of a professional physician according to the individual’s condition. There are differences between the two drugs in terms of indications, adverse reactions, precautions and so on. 1. Indications: PTX is mainly applicable to pharyngitis and tonsillitis caused by purulent streptococcus infection, sinusitis, otitis media, oral abscess, skin and soft tissue infections, acute bronchitis, Mycoplasma pneumoniae and other diseases caused by sensitive bacteria. Clarithromycin is suitable for sinusitis, bronchitis, pneumonia, pharyngitis, salpingitis, odontogenic infections and other diseases. 2. Adverse reactions: although both PTX and Clarithromycin may cause gastrointestinal discomfort, PTX is mostly manifested in middle and upper abdominal pain, pain in the mouth and tongue, gastrointestinal loss, etc., and individual patients may also have fever, liver function abnormalities, allergies. Clarithromycin mostly manifested in abdominal pain and diarrhea, nausea and vomiting, abnormal taste, insomnia and so on. 3. Precautions: Interfering with the bactericidal activity of penicillins, it is forbidden to use it for those who are allergic to this drug. Clarithromycin and cisapride, pimozide, ergotamine or dihydroergotamine, oral midazolam, terfenadine and other drugs, in addition to hypokalemia, severe renal insufficiency, allergic to this drug, prohibit the use of drugs. Cross-saxomycin and clarithromycin are prescription drugs, the specific use of medication, must be guided by a professional doctor, can not be used at will.