Crohn’s disease colonoscopy is primarily segmental (discontinuous). Colonoscopy in patients with Crohn’s disease is done to examine the whole colon and the end of the ileum. The lesions are segmental (noncontinuous) in distribution, longitudinal ulcers are seen with thick white moss on the surface, the mucosa around the ulcers is normal or cobblestone-like, the intestinal lumen is narrowed, there are inflammatory polyps, and the appearance of the mucosa is normal between the segments of diseased bowel. Deep biopsy of multiple lesions sometimes reveals non-caseous necrotizing granulomas or large lymphocytic aggregates in the lamina propria. Inflammatory lesions of the bowel are seen as coarse and disorganized mucosal folds, pseudo-polyps, and cobblestone signs called jumping signs. Patients should be treated symptomatically according to the colonoscopy report and under the guidance of a physician.