The side effects of Sertraline are mainly in the following 3 aspects: 1. Gastrointestinal reactions and other somatic discomfort symptoms. First, gastrointestinal reactions are more common, especially at the beginning of the drug may be more common, such as nausea, vomiting or constipation, diarrhea, but also dry mouth, bitter mouth and other possible side effects, or there are other physical reactions, such as dizziness, headache or physical discomfort, such as muscle tension, which are relatively rare. 2, ejaculation delay and other abnormal sexual function problems. Secondly, the impact on sexual function, especially in men, including the problem of causing delayed ejaculation, may be of more concern to many male patients. 3, causing nocturnal manic episodes or aggravating anxiety and other side effects. Finally, sertraline, as an antidepressant drug, also has a certain risk of transient mania, and may also cause increased anxiety in patients in terms of raising their mood. Of course, as a very commonly used antidepressant drug, the overall effect is very good, the safety is also relatively high, and the side effects are still relatively few.