Low value of glycolic acid is rare clinically, the clinical significance is not clear, the effect of elevated glycolic acid on the human body is mostly seen in the following cases: 1, acute hepatitis, chronic active hepatitis, alcoholic hepatitis, glycolic acid is generated by hepatocytes through the liver-biliary cycle and secreted into the intestine to promote the absorption of food; when liver function is abnormal, the content of glycolic acid increases; 2, pregnant women who develop circumscribed without obvious causes of itching should be alerted to intrahepatic cholestasis syndrome in pregnancy. Glycolic acid sludge in the bile ducts has little effect on the pregnant woman, but the fetus in utero is highly susceptible to intrauterine hypoxia, intrauterine distress and even preterm delivery; 3. Gallstones and hepatobiliary obstructive diseases have early diagnostic significance.