Chronic epididymitis is a common urological disease, mainly caused by pathogenic microbial infection. Most of the patients are not completely cured in the acute attack period and gradually turned into chronic, showing pain and swelling and other discomfort. The main treatment for patients with chronic epididymitis is antibiotic medication, such as levofloxacin. Local can also elevate the scrotum, magnesium sulfate wet compresses and so on to relieve the symptoms. At the same time, pay attention to have more rest, especially avoid fatigue, avoid eating spicy stimulating food. If the local pain is severe and recurrent, affecting the life and work, the epididymectomy can be considered. Therefore, chronic epididymitis is not forever incurable, only the treatment cycle is relatively long. It is recommended to go to the hospital in time for examination and treatment under the guidance of the doctor. Drugs should be applied under the guidance of doctors.