High progesterone in the luteal phase is a normal physiological condition that indicates that the body is producing enough progesterone to favor conception. In this case, if the sperm and egg meet, the chances of conception are very high. In addition, if a fertilized egg is formed in the luteal phase, it will also lead to an increase in the body’s production of progesterone to maintain the needs of a normal pregnancy. Therefore, in case of delayed menstruation, it is advisable to go to the hospital for a checkup to determine whether you are pregnant or not. In pathological cases, if there is high progesterone in the luteal phase, consider the presence of hyperemesis gravidarum as well as diseases such as chorionic epithelial carcinoma, lipoid ovarian tumors and corpus luteum cysts. All of these diseases cause a large and constant increase in progesterone, with the exception of luteal cysts, which fall after rupture or resorption of the cyst. The diagnosis can be confirmed by blood tests as well as ultrasound and biopsy, among which gravidarum and chorionic epithelial carcinoma require prompt treatment.