Cigarette smoking can aggravate cirrhosis. Cigarette contains nicotine, active oxides, polycyclic aromatic hydrocarbons, and many of these substances are carcinogenic, cytotoxic, antigenic and mutation-inducing, etc., which can affect the secretion of inflammatory factors and the homeostasis of the internal environment. Cirrhosis refers to a variety of pathogenic factors, the liver undergoes chronic inflammation, steatosis, hepatocytopenia, diffuse fibrosis and intra- and extra-hepatic vascular proliferation gradually developing into cirrhosis. Smoking produces a variety of substances in the body that can lead to chronic inflammation and extensive cellular damage, thus aggravating cirrhosis. Therefore, patients with cirrhosis should quit smoking. If discomfort occurs, it is recommended to consult a doctor in a timely manner to clarify the cause of the disease and target treatment under the guidance of the doctor.