Leg swelling after chemotherapy, need to clarify the cause, and then further treatment, as follows: 1, chemotherapy drug impact: caused by hypoproteinemia or poor kidney function, leg swelling, need symptomatic treatment, such as the application of drugs to elevate albumin, infusion of human albumin, enhance nutrition, oral quality protein, etc., can improve leg swelling, if the kidney function is poor, also need to consider the application of kidney preservation drugs, there Sometimes it is necessary to suspend chemotherapy and apply symptomatic treatment drugs to relieve symptoms; 2. Poor venous return: the way of elevating bilateral lower limbs while lying down can be used, which is also beneficial to reduce swelling. In addition, chemotherapy may trigger multi-systemic side effects, so regular blood checks are needed after chemotherapy, including blood routine, liver and kidney function tests.