When patients take propylthiouracil the following side effects may occur, more commonly seen as rash or itchy skin, some rashes may develop into exfoliative dermatitis, and may cause adverse reactions in the blood system, mostly mild granulocytopenia, rarely severe granulocyte deficiency, thrombocytopenia, prothrombin reduction or coagulation factor VII reduction, also seen in aplastic anemia. Other possible effects include loss of taste, nausea, vomiting, epigastric discomfort, arthralgia, dizziness, headache, vasculitis, lupus erythematosus-like syndrome, and rare adverse reactions include hepatitis, which may develop into jaundice and may last up to 10 weeks after discontinuation of the drug, and may cause interstitial pneumonia with cough and shortness of breath, and may cause nephritis and vasculitis involving the kidneys, therefore, during the use of the drug It is important to check the blood picture and liver function regularly.