Depending on the cause, ankle pain after running can be treated with general therapy, medication, physical therapy and surgery, etc. It is considered to be related to incorrect running posture, sprains, rheumatoid arthritis, and articular cartilage injury. 1. Incorrect running posture: bad running posture will cause ankle joint pain, which can be relieved after sufficient rest, and the posture should be corrected in the next run. 2. Sprain: not doing sufficient preparation before running can lead to sprain of the ankle, which may cause localized edema and pain, etc. Local cold compresses can be applied after the injury. After the injury, local cold compresses can be applied to shrink blood vessels and reduce edema, which usually lasts for about 15 minutes. Safflower oil and other medicines can be applied to the painful parts and sufficient rest can be paid attention to, and ibuprofen and other medicines can be taken orally to relieve pain if necessary. 3. Rheumatoid arthritis: it can involve the ankle joint to cause arthritis, resulting in localized edema, inflammation of the ankle, ankle pain under the stimulation of running. Anti-rheumatic drugs (e.g. leflunomide), non-steroidal anti-inflammatory drugs (e.g. diclofenac) and other treatments are needed. 4. Articular cartilage injury: due to long-term over-running, the cartilage of the ankle joint is severely worn out, and ankle pain can occur, attention should be paid to rest, reduce running, physical therapy such as baking, hot compresses, etc., and pain relieving drugs such as Celecoxib can be taken orally. If conservative treatment is not effective, arthroscopic surgery is feasible. There may be other causes of ankle pain after running, such as osteoarthritis, etc. If the symptoms don’t improve after resting, you should consult a doctor as soon as possible for a relevant examination to clarify the cause of the disease, and then carry out standardized treatment under the guidance of a doctor. The above drugs should be used under the guidance of a doctor.