Patient knee ligament pain, commonly due to traumatic factors, degenerative osteoarthritis of the knee, as follows: First, traumatic factors: knee trauma, such as joint sprain or impact, will lead to knee ligament injuries, the patient will have obvious pain, swelling, activity limitation, MRI can be found ligament injury degree and location, timely conservative treatment, surgical treatment, able to make ligament injury quickly recovered. In time, through conservative treatment and surgical treatment, the ligament injury can be rapidly recovered. Secondly, degenerative osteoarthritis of knee joint: patients with degenerative osteoarthritis of knee joint will have serious osteophytes, and if the osteophytes appear in the stopping point of ligaments or walking parts, the patients will have ligament pain in knee joint, such as medial collateral ligament, medial collateral ligament affected by tibia and distal femur, proximal osteophytes, which will be obviously manifested as pain, and the range of motion of the patient’s joints will be affected as well. Therefore, patients with ligament pain in the knee should be diagnosed and treated promptly.