Urethral blisters are recommended to go to the hospital for further examination to determine the cause of the disease before deciding how to use drugs to deal with it. 1, if the diagnosis of herpes virus infection, it is recommended to apply acyclovir ointment, 3-4 times a day, for 7-10 days, and need to take acyclovir capsule 400mg, 3 times a day, for 10 days. 2, if the diagnosis of urethral cysts, the size of the smaller, generally do not use drugs. If there is a local bacterial infection, it is recommended to apply Bactroban ointment or erythromycin ointment 3 times a day for 1 week to observe whether the symptoms are relieved. 4. If there is excessive local irritation or allergy, it is recommended to apply a small amount of mometasone furoate cream 3 times a day for 3 consecutive days, according to the local blisters subside, or the local symptoms subside, to decide whether to continue to use in the later stage.