Aspirin is a very common anti-thrombotic drug, and is an essential basic drug for patients with coronary heart disease and stroke. However, many people believe that aspirin is damaging to the stomach and should be taken after meals, but this is not the case. At present, the aspirin sold in China is basically aspirin enteric tablets. Enteric tablets are designed to avoid aspirin being absorbed in the stomach. The enteric coating is not broken down in the acidic environment of the stomach, and it is only in the alkaline environment of the intestine that aspirin is released to take effect. This design greatly reduces the damage to the stomach and changes the way aspirin is taken – from after a meal to on an empty stomach. This is because after a person eats, the acidic environment of the stomach may be altered and the enteric coating of aspirin enteric tablets may disintegrate prematurely, so taking it after a meal may instead damage the gastric mucosa. So many people take aspirin enteric tablets before breakfast instead, is this right? In fact, this is still incorrect. Take aspirin before breakfast, because the time is very close to the eating time, aspirin is simply too late to run to the intestine, the result is still mixed with food, the risk of early decomposition greatly increased. So at what time should you take aspirin enteric tablets better. A few years ago I looked up some information on this subject and asked a gastroenterologist. First, according to what the gastroenterologist told me, it takes at least 2-3 hours for an aspirin enteral tablet to enter the intestine in the fasting state. And it also takes about 3 hours for the stomach to empty after a meal, so that there is no good point in time to meet this requirement either before breakfast, and between three meals, while bedtime is generally more than 3 hours before dinner, which can be considered fasting, and the gastric pH should be sufficient to ensure acidity. Secondly, most cardiovascular adverse events occur in the early morning and morning, and it takes more than 3-4 hours for oral aspirin to be absorbed into the bloodstream, so taking it at breakfast does not cover the morning peak period well, while taking it at bedtime allows the blood concentration to peak in the early morning, making aspirin more effective. I have actually met several patients who were taking aspirin in the morning and often felt upset in their stomachs, which improved when they switched to bedtime dosing. In fact, in the last few years, the medical staff in my department has basically accepted the aspirin enteric tablets at bedtime. It is also important to note that aspirin enteric tablets should not be broken or crushed, otherwise the enteric coating will lose its effect and increase gastrointestinal adverse reactions.