Diabetic foot is one of the major complications of diabetes mellitus, and the incidence of diabetic foot in diabetic patients is 15%. Diabetic foot ulcer (DFU) is also known as diabetic gangrene of the extremities, the patient due to the chronic progressive lesions of nerves, blood vessels, so that the organization of the resistance to infection and the ability to repair decreased, a slight crush injury or skin breakage can lead to infection, the occurrence of long-lasting ulcers, gangrene of the extremities, and in serious cases, need to amputate the limbs. It is characterized by long duration, high cost and high disability rate, and it is the longest hospitalization reason for diabetic patients. It poses a serious threat to the quality of life of diabetic patients and a heavy burden on their families and society. The pathogenesis of diabetic foot ulcers combined with PAD is still not fully understood, and there are many factors affecting PAD. The aim of this paper is to understand the risk factors associated with the development of PAD, and through the control of these related risk factors, to achieve the purpose of preventing the occurrence and development of the disease, reduce the amputation rate, and improve the quality of life of patients.