When rectal cancer recurrence occurs with abdominopelvic fluid accumulation, the prognosis of the disease can be improved through drug treatment and abdominopelvic puncture and fluid extraction, etc. It is recommended to consult professional doctors for specific treatment. After the recurrence of rectal cancer, radiotherapy, chemotherapy and targeted therapy can be used to inhibit the malignant proliferation of tumor cells, shrink the recurrent lesions and improve the prognosis of the disease. Chemotherapy drugs commonly used to treat rectal cancer recurrence include methotrexate, fluorouracil, cisplatin, etc. Targeted drugs include cetuximab, bevacizumab, etc., which need to be used in strict accordance with doctor’s prescription. After the recurrence of rectal cancer with abdominal and pelvic fluid accumulation, abdominal or pelvic puncture and fluid extraction or intracavernous injection of chemotherapeutic drugs can be used to reduce the production of abdominal fluid accumulation, and the treatment can be given according to the condition and under the guidance of doctors. Therefore, it is recommended to go to regular hospitals to receive standardized treatment as soon as possible when there is rectal cancer recurrence with abdominopelvic effusion.