There is no clinical statement about which is the best toothache painkiller, and generally toothache sufferers can follow the doctor’s instructions to relieve the pain with non-steroidal anti-inflammatory drugs such as ibuprofen and acetaminophen. There are many causes of toothache, such as dental trauma, caries, pulpitis, apical periodontitis, periodontal abscess, wisdom tooth pericoronitis. Dental lesions can often cause patients to experience sharp pain, throbbing pain, swelling pain, irritation pain, etc. For those with obvious pain symptoms, if necessary, you can follow the doctor’s orders with ibuprofen, acetaminophen, celecoxib and other non-steroidal anti-inflammatory drugs to relieve pain. If the local teeth are accompanied by localized inflammation, chlorhexidine gargle can also be used to control inflammation and assist in relieving swelling and pain; some patients can also be relieved of pain by applying local ice packs. In addition to the above treatments, patients need to cooperate with the doctor to take other related treatment measures according to the condition, so as to achieve the purpose of treating the disease and improving the toothache. It is recommended that toothache sufferers use medication under the guidance of a doctor, and not indiscriminate use of medication on their own. Pay attention to daily oral care, brushing and gargling.