Many patients drink saffron in water as a substitute for tea in order to prevent or treat coronary heart disease. Is this practice feasible? Safflower is an extremely widely used herbal medicine in clinical practice. It is pungent and warm in nature, enters the heart and liver meridians, and has the effect of activating blood circulation, removing blood stasis and relieving pain. It is used in the treatment of angina pectoris in coronary heart disease, together with Chuanxiong and Salvia. Chinese medicine is based on evidence-based treatment, and the treatment of coronary artery disease is based on the combination of deficiency and reality, which is the main method to invigorate the blood and at the same time to supplement the deficiency of heart qi and heart yin. In addition, “all drugs have three toxins”, pharmacological research shows that when safflower is taken in improper doses, it has an inhibitory effect on the heart, slowing the heart rate and weakening myocardial contractility. The side effects such as abdominal pain, diarrhea and other gastrointestinal reactions, bleeding and so on. It is recommended that caution must be exercised when using saffron.