Metformin Glipizide Tablets are recommended to be taken with a meal, with a recommended starting dosage of 250mg/2.5mg once daily, the exact dosage should be set by your doctor based on your blood sugar. Metformin Glipizide Tablets are recommended to be taken with a meal, with a starting dose of 250mg/2.5mg once daily, and when an increase in dose is required, it may be taken by increasing one tablet per day every 2 weeks, up to a maximum dose of 1000mg/10mg. Contraindications for metformin glipizide tablets include acute myocardial infarction, sepsis, nephropathy or renal insufficiency, heart failure, acute and chronic metabolic acidosis, patients with hypersensitivity to sulfonylureas or metformin, and so on. Use with caution in pregnancy, children, and the elderly. Common adverse reactions are hypoglycemia, upper respiratory tract infection, diarrhea, and headache. Metformin Glipizide Tablets is a combination of Metformin and Glipizide, both of which are hypoglycemic agents for patients with type 2 diabetes mellitus who are poorly controlled by diet and exercise. Glipizide lowers blood glucose by stimulating the release of insulin from pancreatic β-cells, and metformin lowers blood glucose by decreasing hepatic glucose production, increasing peripheral glucose uptake and utilization, and improving insulin sensitivity. Metformin Glipizide Tablets, as a prescription hypoglycemic agent, must be used and dosage adjusted under the supervision of a medical professional to avoid risks.