Glutamyl transferase is abundant in the kidney and liver, but in the serum, glutamyl transferase mainly comes from the hepatobiliary system. When there is hyper-synthesis or obstruction of bile drainage in the liver, glutamyl transferase will be elevated. The following are common clinical causes: 1. Biliary obstruction diseases: such as primary biliary cirrhosis, chronic cholestasis caused by sclerosing cholangitis, and liver cancer, due to obstruction in the liver, will induce hepatocytes to produce a large amount of glutamyl transferase, while cancer cells also synthesize glutamyl transferase, resulting in abnormal elevation of glutamyl transferase; 2. abnormally elevated; 2. acute and chronic hepatitis, cirrhosis: will cause increased glutamyl transferase, but its elevation is lower than that of biliary obstruction disease; 3. acute and chronic alcoholic hepatitis and drug-related hepatitis: glutamyl transferase is often higher; 4. other diseases: such as pancreatitis, pancreatic tumor, prostate tumor, kidney disease, etc., can also lead to mildly elevated glutamyl transferase; 5. drugs: in addition to the liver itself In addition to diseases of the liver itself, drugs are also a major cause of elevated glutamyl transferase, drug-induced elevated glutamyl transferase can occur in healthy people without a history of liver disease, such as some patients with hyperlipidemia who take statins, which can have the side effect of elevated glutamyl transferase. But if it is so for a long time, it is highly suggestive of the need to replace the drugs; 6, lifestyle habits: certain lifestyle habits can also lead to high glutamyl transferase, such as strenuous exercise, excessive fatigue, alcohol consumption, greasy diet, irregular work and rest, even anger and other bad lifestyle habits, which can cause transient glutamyl transferase elevation.