To reduce high cholesterol, under the guidance of a doctor to control diet and oral statin therapy, if necessary, subcutaneous injection of PCSK9 inhibitors, there is no fastest clinically. 1. Dietary control: patients with elevated cholesterol should strictly control their diet, eat more green and fresh vegetables, and limit the intake of high-fat foods. 2. Oral medication: Patients with hyperlipidemia can be treated with oral statins, commonly used drugs include atorvastatin, which can inhibit cholesterol synthesis, and patients with severe elevated cholesterol can be combined with cholesterol absorption inhibitors to increase the effect of lipid-lowering drugs. 3. Subcutaneous injection: For severe hyperlipidemia, such as familial hyperlipidemia with high cholesterol levels, PCSK9 inhibitors can be injected subcutaneously for treatment. Patients with elevated cholesterol should choose specific treatments under the guidance of a physician and should not blindly use medication on their own.