Numbness and pain in the limbs while sleeping may be caused by diabetes mellitus, cervical spondylosis, multiple myeloma, cerebrovascular diseases and so on. 1. Diabetes mellitus: metabolic disorder caused by insufficient insulin secretion or utilization disorder, patients will have excessive drinking, eating and urination, and some patients will also have peripheral neuropathy, causing numbness and pain in the limbs. 2. Cervical spondylosis: If the patient has numbness and pain in the limbs along with neck pain, dizziness and other symptoms, cervical spondylosis should be considered. 3. Multiple myeloma: malignant proliferative disease of plasma cells in bone marrow, patients will have anemia, bone pain, numbness and pain in limbs and other symptoms. 4. Cerebrovascular disease: Especially for those who have hypertension, diabetes mellitus, hyperlipidemia and other basic diseases, the symptoms of numbness and pain in the limbs may appear at night when they sleep due to the lowered metabolism of the body and slow blood flow, which may easily induce acute cerebrovascular disease. Common diseases include acute cerebral infarction, cerebral hemorrhage and so on. Numbness and pain in the limbs during sleep may also be caused by other diseases, and it is recommended that the patient consult a doctor in time to clarify the cause. Under the guidance of the doctor to use reasonable means of treatment.