Protein may refer to urine protein and hemoglobin, both elevated proteins have different clinical significance, and may be elevated for physiological reasons, not always a harbinger of disease. 1. High urine protein: high urine protein may occur after strenuous exercise or in women who are pregnant, and this is a physiological cause. It may also be caused by kidney diseases such as glomerulonephritis, lupus nephritis, kidney tumor, pyelonephritis and so on. Myeloma, heavy metal poisoning and other conditions can also lead to an increase in protein secretion by the urinary system and elevated urine protein. 2. Hemoglobin: Hemoglobin is a special protein that transports oxygen in red blood cells. It may be physiologically elevated in newborns or plateau dwellers. Diseases such as congenital heart disease, pulmonary heart disease, true erythrocytosis, anemia, leukemia, and hookworm disease usually cause pathologically elevated hemoglobin as well. Excluding physiologic causes of elevation, if a patient develops a pathologic elevation, prompt medical attention is recommended to identify the cause and treat it.