Helicobacter refers to Helicobacter pylori. Anti-Helicobacter pylori treatment is needed after H. pylori exceeds the standard, which is a common cause of gastritis, peptic ulcer, gastric cancer and other diseases. Currently, a four-pronged treatment regimen of “proton pump inhibitor + 2 antibiotics + bismuth” is generally adopted for H. pylori overload. Proton pump inhibitors such as omeprazole, rabeprazole, etc. can inhibit the secretion of gastric acid, but also can enhance the bactericidal effect of antibiotics against Helicobacter pylori; antibiotics can be selected from clarithromycin, amoxicillin, metronidazole, tinidazole, quinolones, etc., the choice of drugs and the use of treatment should be based on the patient’s condition and resistance to drugs. Bismuth such as bismuth potassium citrate, bismuth pectin, etc. Bismuth can block gastric acid, pepsin on the mucous membrane of the self-digestion, but also through the wrapping of the bacterium to interfere with the metabolism of Helicobacter pylori, to play a bactericidal role. The use of the above drugs should be guided by a professional doctor; the efficacy of antibacterial treatment needs to be tracked, and it is generally recommended that H. pylori be retested at least 4 weeks after treatment. Due to the emergence of drug-resistant strains, adverse reactions to antimicrobial drugs, poor patient compliance and other factors, some patients infected with H. pylori are difficult to eradicate, and a reasonable treatment program should be developed for each individual.