Gastric mucosal cell atrophy refers to the long-term stimulation of gastric mucosa in various reasons, leading to changes in the structure of gastric mucosal epithelium, gastric mucosal proliferation ability decreased, resulting in atrophy, and need to be treated according to the relevant causes. Prolonged irregular diet and overeating may lead to atrophy of gastric mucosa cells, which requires adjustment of living habits and regular diet. Helicobacter pylori infection may also lead to gastric mucosal cell atrophy, which requires a comprehensive examination in the hospital and standardization of quadruple therapy, i.e., the combination of 2 antibiotics, such as amoxicillin and clarithromycin, bismuth, and proton pump inhibitors, such as omeprazole. Chronic gastritis may also lead to gastric mucosal cell atrophy, at this time, you need to pay attention to avoiding the intake of spicy food, stimulating food, etc. in general. If there is gastric mucosal cell atrophy, you should consult a doctor in time and follow the doctor’s instructions for treatment.