Diabetic nephropathy is a common complication of diabetes mellitus, one of the manifestations of diabetic systemic microangiopathy, clinically characterized by proteinuria, edema, hypertension, progressive renal impairment, and severe renal failure in the late stage, and is one of the main causes of death in diabetic patients. With the prolongation of life expectancy of our population, the change of living habits and diet structure, the prevalence of diabetes is on the rise and diabetic nephropathy is also increasing, early protection of the kidneys must do the following 8 points. First, control the blood sugar to meet the standard: since the discovery of diabetes, it must be treated, the treatment must meet the standard. Control HbA1C <7%; Second, regular monitoring of blood sugar levels: regular monitoring of blood sugar, regular monitoring of urine protein and blood pressure levels are necessary. Third, control blood pressure to normal levels: hypertensive patients with diabetes, blood pressure should also be controlled lower, blood pressure should be <130/80 mmHg; hypertensive patients with renal impairment, blood pressure should be controlled at 125-130/75-80 mmHg or less to delay the development of renal impairment. Fourth, reduce sodium intake: patients with kidney disease must control the intake of sodium and salt. V. Reasonable diet: the required protein intake is 0.6?0.8g/kg/d, which should be mainly high quality animal protein. Under the guarantee of insulin, the intake of carbohydrates can be increased appropriately to ensure that there are enough calories to avoid the increase of protein and fat decomposition, which increases the burden of renal excretion. In addition, reduce the intake of various high-calorie fried foods and crude protein, which is beneficial to the protection of the kidney. Sixth, early interventional treatment: early interventional treatment for diabetic patients is effective, and the application of antioxidants such as vitamin E and vitamin C, vascular converting enzyme inhibitors, and traditional Chinese medicine Liu Wei Di Huang Wan for interventional treatment have achieved good results. Of course, minimize the damaging effect of hypoglycemic drugs on the kidney and apply insulin early to protect the kidney. Seven, taking angioconverting enzyme inhibitors (e.g. Lortinexin, Monox) in type 1 diabetes and type 2 diabetes, and taking angiotensin II receptor antagonists (Ambrovir, Dextran) in type 2 diabetes to control blood pressure <130/80 mmHg has been proved to delay the progression of diabetic nephropathy. Its protective effect on the kidney is the result of its antihypertensive effect and direct action. Eight, avoid the use of nephrotoxic drugs: avoid the use of drugs harmful to the kidneys: such as gentamicin, streptomycin, butamycin and some herbal preparations.