A twisted knee that is not straight may be related to knee ligament injury and knee meniscus injury, which can be treated by using anti-inflammatory and analgesic drugs and meniscus repair surgery. Knee ligament injury is caused by overloading of the ligaments when the knee is sprained and the ligament fiber bundles are ruptured or torn, resulting in local congestion and swelling, leading to dysfunction of the joints, resulting in the knee not being straight. It can be treated by using anti-inflammatory and analgesic drugs, such as indomethacin and ibuprofen, etc. Surgery is needed in serious cases. Meniscus injury of the knee is caused by intense internal rotation of the femur when twisting the knee, the medial meniscus is subjected to rotational pressure between the femoral condyles and the tibia resulting in a tear of the meniscus, and symptoms such as obvious pain, swelling, and fluid accumulation in the knee are present. It is necessary to go to the hospital to receive treatment such as meniscus repair surgery. Patients who have twisted their knees and can’t straighten them should go to regular hospitals for examination, and cooperate with doctors for active treatment after clarifying the cause of the disease, so as to avoid aggravation of the disease and affecting the normal life.