Talking about the HPV vaccine HPV, also known as human papillomavirus, has a high rate of infection in the population and can infect the genital tract in a variety of ways leading to condyloma and cervical lesions in women. Vaccination is an effective way to prevent HPV infection. What vaccines are currently available in China? Domestic bivalent HPV vaccine (E. coli), bivalent HPV adsorbed vaccine, quadrivalent HPV vaccine, and nine-valent HPV vaccine; Speaking of several prices, we have to talk about HPV virus The cervical cancer screening we usually do includes HPV virological examination and cytological examination (most commonly TCT) There are more than 100 subtypes of HPV virus, common high-risk types, the most common for Asian women are 16/18 and 12 other high-risk types. For Asian women, the most common type is 16/18, and there are 12 other high-risk types: 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68. A single HPV test is recommended for cervical cancer screening for women before the age of 25, and a combined HPV and cytology test is recommended after the age of 25. Both the bivalent adsorbed vaccine, the domestic bivalent HPV vaccine, and the quadrivalent vaccine protect against HPV16/18 high-risk-related CIN2-3 (high-grade cervical intraepithelial neoplasia), AIS (carcinoma in situ), or cervical cancer, and clinical trials have shown protection of 87.3%-100%. The two extra subtypes of the quadrivalent vaccine are HPV6/11, which are low-risk HPV virus subtypes that protect against benign lesions such as condyloma acuminata. After the quadrivalent, you may know, that the nine-valent vaccine contains which HPV virus subtypes? In addition to HPV16/18 and HPV6/11, which are included in the quadrivalent vaccine, it also includes the common infection subgroups of East Asian women, with 100% protection against HPV31/33/45/52/58-related CIN1+ (low-grade cervical intraepithelial neoplasia). So should I be vaccinated? In 2020 the American Cancer Society (ACS) released the HPV Vaccination Guidelines, which no longer recommends HPV vaccination for women over the age of 26. However, in combination with the epidemiological characteristics of cervical cancer in China and the low coverage of cervical cancer screening, as well as the efficacy of HPV vaccine protection in women aged 27-45 years, our strategy of individualized HPV vaccination is necessary. HPV vaccination is recommended as a priority for women aged 9-26 years, especially before the age of 17 years; HPV vaccination is also recommended for women aged 27-45 years who are eligible. How many vaccines should I choose for my vaccination? From what I have told you above about the viruses targeted by the vaccine, it must be clear to you that in fact, vaccination is not about choosing the so-called several-valent vaccine, but about early vaccination. The effectiveness of the bivalent vaccine in preventing cervical cancer is comparable to that of the quadrivalent and nine-valent vaccines. The five additional subtypes of the nine-valent vaccine target CIN1+ (low-grade cervical intraepithelial neoplasia), and most of the low-grade cervical lesions can heal on their own. So it’s time to change the phenomenon that the nine-valent vaccine is hard to find! A few questions about HPV vaccination 1. Can I still get vaccinated if I am infected with HPV virus? Of course you can! HPV vaccine has significant protective effect for women with previous HPV infection of vaccine type. 2. Can I be vaccinated for cytological abnormalities (most commonly TCT abnormalities)? Yes, it has a high protective effect. 3.Do I need to be routinely screened for cervical cancer before vaccination? HPV vaccination is recommended for women of appropriate age regardless of the presence of abnormalities. 4.Can women who are pregnant or breastfeeding be vaccinated with HPV vaccine? Preventive HPV vaccination is not recommended for women who have recently prepared for pregnancy, are pregnant, or are breastfeeding. Key considerations: HPV vaccine is a preventive vaccine and cannot treat HPV infection and related diseases; HPV vaccine contains a limited number of genders (and some specific types of cervical cancer are not related to HPV infection), and cervical cancer screening is still required after vaccination.