Gui Yuan Qiong Yu Granules is suitable for gray hair caused by deficiency of qi and yin, while it is not effective in treating gray hair caused by other reasons. Gui Yuan Qiong Yu Granules is composed of Gui Yuan, Radix Rehmanniae Praeparata, Radix Polygoni Multiflori, Poria, Radix Poria, Radix Codonopsis Pilosulae, Radix Chasteberry, Pericarpium Citri Reticulatae, etc. It has the efficacy of tonifying the heart and spleen, nourishing the blood to calm the mind, nourishing the liver and kidneys, and nourishing yin to darken hair. It can be used for deficiency of qi and yin, withering and wasting of fluid, loss of blood due to labor, palpitation, dizziness, forgetfulness, insomnia, and premature whitening of hair. The adverse reactions and contraindications of Gui Yuan Qiong Yu Granules are not clear, where the spleen and stomach weakness, vomiting and diarrhea, abdominal distension and loose stools (feces thin and unshaped), cough and phlegm, diabetic patients should be used with caution. Guiyuan Qiongyu Granules should be taken before meals. If there is no significant improvement in symptoms or worsening of symptoms during two weeks or during the period of taking the medicine, or new serious symptoms appear, the medicine should be stopped immediately and go to the hospital for consultation.