It is not advisable to drink coffee when taking cephalosporin, the caffeine in coffee will affect the efficacy of cephalosporin, there is no obvious side effect, it will have a bad effect on the efficacy of the medicine, caffeine has a very clear effect of weakening cephalosporin. If you have to drink it, the two should be taken 1-2 hours apart. In principle, cephalosporin and any antibiotic drugs should not be taken at the same time, the main effect of coffee is to stimulate the nerves, and taking it at the same time with other drugs will cause certain effects. Cephalosporin is an anti-inflammatory drug, in the case of avoiding drinking coffee at the same time, you should also abstain from spicy food as well as drinking alcohol. Pay attention to a light diet, eat more fresh fruits and vegetables, do not use cephalosporin blindly, it is best to take it under the advice of a doctor, and try not to drink coffee while taking cephalosporin, and drink coffee 24 hours after stopping it.