Arteriosclerosis is a systemic disease, lower extremity atherosclerosis will lead to narrowing or occlusion of the lower extremity blood vessels, resulting in a reduction in blood supply to the lower extremity, the patient appears walking muscle pain that is intermittent claudication, with the aggravation of the disease, further reduction in blood supply to the lower extremity, it will lead to ischemic rest pain or even gangrene of the affected limb toes, gangrene is bound to develop to the point of amputation if not treated in a timely manner. Lower limb ischemia can be divided into the following four stages: Stage I: early limb pallor, cold, cold fear, numbness and discomfort, dullness of sensation. Phase II: intermittent claudication, also known as motor pain, is a typical symptom of lower limb ischemia. (Often mistaken for low back pain or osteoarthritis.) It mostly occurs in the calf area and is characterized by weakness, pressure, numbness, dull pain and spasmodic sharp pain in the limb after the patient walks for a certain distance. It is relieved after standing and resting for a while, but continued walking can produce the same symptoms, and the shorter the walking distance, the more severe the condition. Stage III: Resting pain: It is the clinical manifestation of severe deficiency of blood supply to the arteries of the lower limbs, especially the pain is significantly aggravated at night, so that patients with severe disease sit on their knees, moaning and cannot sleep flat. Stage IV: toe rupture and gangrene: clear borders, deep ulcers, black necrotic tissue, obvious pain, or accidental injury to the limb and toe rupture, which cannot heal even after 1-2 weeks, then timely medical attention should be sought to prevent the rupture from continuing to expand, or even amputation. Smoking, obesity, hyperlipidemia, vascular endothelial dysfunction, hypertension, and diabetes are all high-risk factors for arterial ischemia in the lower extremities. Among them, the incidence of lower extremity arterial ischemia in diabetic patients is 11 times higher than that in non-diabetic patients, on the other hand 20% of patients with intermittent claudication develop diabetes.