After skull defect, timely skull repair is not only beneficial to the patient’s recovery, but also can effectively avoid some skull syndrome. If the defect is not repaired for a long time, the brain will lose the protection of the skull and will bring great damage to the brain tissue under the impact or force of external force on the head. Therefore, it is important to repair cranial defects in a timely manner regardless of the cause of the defect in life. Although, skull repair as a relatively routine surgery in neurosurgery, it will not cause any damage to the brain and blood vessels supplying the brain, and the majority of neurosurgeons and experienced doctors will not pose any risk to patients when they complete this surgery. However, after clinical research, it was found that titanium mesh cranial repair, at present, still has some defects, and the common problems are postoperative rejection, infection, chronic pain, and material exposure, so it cannot be used as the first choice of repair for patients. In recent years, with the emergence and clinical use of polyetheretherketone peek material cranial repair plastic surgery, the majority of patients with cranial defects have seen a new hope. At present, a new type of polyetheretherketone peek material cranioplasty is introduced in the clinic. This technology has four technical innovations compared with the cranial bone repair surgery carried out in other hospitals, on the basis of neurosurgical repair, further plasticization is done on the appearance, and the repair and plasticization are cleverly connected together, which can effectively avoid the problems of temporal muscle atrophy and asymmetry on both sides after the surgery; in addition, the cranial bone repair and plastic surgery of polyether ether ketone peek material uses the new artificial material peek as the implant material, and the properties of peek are also very close to those of human. The performance of peek is also very close to the human skull, and there is basically no discomfort after surgery.