Both eszopiclone and zolpidem have hypnotic effects, and the effectiveness of the drug needs to be determined by the purpose of the medication. Eszopiclone is a medium- to long-acting non-benzodiazepine with sedative, hypnotic, and anxiolytic effects, and can be used for patients with difficulty falling asleep, sleep disorders, and early awakening. However, because eszopiclone is medium- to long-acting, it may have a greater effect on the next day, and some patients may experience adverse effects such as sleepiness and fatigue upon awakening on the second day. It should not be taken by those suffering from alcoholism, liver or kidney insufficiency, glaucoma, and the elderly population. Zolpidem Acid is a new type of sedative-hypnotic drug, belonging to the non-benzodiazepine class of drugs. It is used in patients with difficulty in falling asleep and episodic insomnia, but since it is a short-acting preparation, it has less impact on the activities of the next day. People suffering from respiratory insufficiency, hepatic insufficiency, lactose intolerance, and allergy to zolpidem should not use zolpidem. Eszopiclone and zolpidem are indicated for different groups of people, and the appropriate medication should be chosen according to the patient’s condition and under the guidance of the doctor.