Colds that can cause eye pain are one of the most common clinical manifestations of upper respiratory tract infections. In particular, the mucosa of the upper respiratory tract shows pathological changes of congestion, edema and exudation of inflammatory substances, and the immune response is strong. Since the soft tissues of the five senses are interconnected through blood circulation and lymphatic circulation, respiratory tract inflammation can involve the eye, causing capillary congestion and edema in the eye, and even exudation of inflammatory substances, and the appearance of eye pain, such as pharyngoconjunctival fever, which is a special type of upper respiratory tract infection. At this time it is still necessary to focus on symptomatic and etiologic treatment, taking cold and flu medicines and antipathogens can relieve the symptoms of eye pain.