Children’s vaccine quadruple and quintuple can not be mixed, quadruple and quintuple vaccine is a certain difference, for children’s vaccination should strictly follow the doctor’s instructions, to avoid blind mixing, in order to avoid the occurrence of adverse reactions to vaccination, is not conducive to children’s health. The four and five vaccine types are different, the four vaccine is mainly to prevent diphtheria, whooping cough, tetanus and Haemophilus influenzae type B infection and other infectious diseases; five vaccine in addition to preventing the four vaccine contained in the infectious diseases, but also able to prevent poliomyelitis disease. Both DPT4 and DPT5 vaccines belong to the second category of self-funded vaccines. The two vaccines are given at different ages, with one injection each at three, four and five months and a booster injection at 18 months for the quadruple vaccine, and one injection each at two, three and four months for the pentavalent vaccine, and a booster injection at 18 months for the pentavalent vaccine. The two vaccines should not be mixed, and it is recommended that they be administered according to schedule under the guidance of a doctor.