Waking up with a stuffy ear on one side may be a normal phenomenon caused by pressure on the ear due to sleeping on the side, or it may be caused by cerumen impaction, cold or secretory otitis media. 1. Cerumen impaction: usually caused by excessive accumulation of cerumen in the external auditory canal, when cerumen impaction in one ear leads to an increase in pressure in the ear canal of that side, it may cause one-sided ear stuffiness when waking up from a sleep, accompanied by itching of the ears, tinnitus and other symptoms. 2. Cold and flu: If you catch a cold and flu at night, it will cause the nasal mucosa to swell, which will affect the drainage function of the Eustachian tube and cause more secretions to accumulate in the middle ear canal, which may cause unilateral ear stuffiness when you wake up from a sleep. 3. Secretory otitis media: the disease can lead to the weakening of the Eustachian tube, resulting in the Eustachian tube can not effectively regulate the air pressure in the tympanic chamber, which may cause a sleep after waking up on the one side of the ear stuffy, but also can be accompanied by ear pain, tinnitus and other symptoms. Wake up after a sleep on one side of the ear boring, may be related to other factors, if there are obvious other symptoms of discomfort, should be as soon as possible to consult a doctor, diagnose the cause of the disease, give targeted treatment.