Alpha-glucosidase inhibitors are commonly used as hypoglycemic drugs for patients with type 2 diabetes, mainly for controlling postprandial hyperglycemia. They include acarbose and voglibose. Acarbose is currently commercially available as bactrim and carboplatin, and voglibose is commercially available as bexin. The mechanism of action of α-glucosidase inhibitors is to competitively inhibit glucoamylase, sucrase and isomaltase at the brush border of the small intestinal mucosa, delaying the absorption of glucose and fructose and lowering postprandial blood glucose; reducing the stimulating effect of postprandial hyperglycemia on pancreatic B cells and avoiding postprandial hyperinsulinemia. It has a better effect on the elevation of blood glucose that occurs after eating carbohydrates, and is not effective for the hyperglycemia of eating fatty meals and protein meals. Given the mechanism of action of these drugs, the best time to take them is to chew them together with the first bite of the main meal in order to have a better effect on lowering blood sugar. Take bactrim as an example, if taken half an hour before meal, bactrim enters the intestine and combines with α-glucosidase, and bactrim has dissociated from α-glucosidase when eating half an hour later, at this time carbohydrates can combine with α-glucosidase, making postprandial blood glucose rise and cannot play an effective role in lowering sugar; while if taken after meal, carbohydrates have occupied the α-glucosidase site, and there is no α-glucosidase on the small intestine mucosa. If taken after a meal, carbohydrates have occupied the alpha-glucosidase site, and there is no alpha-glucosidase in the small intestine mucosa that can be combined with bactrim, so taking bactrim after a meal has no effect. Some patients find that they forget to take the drug after eating, and then take the drug again, not only is it ineffective, but it is also a waste of a piece of the drug. We often compare the method of taking Baytan apples to that of the emperor when he goes on a tour of the place to “splash water on the street, yellow soil mat road”, to be just right: if you do it early, the emperor will still be dusty when the water has dried up, you can not see the effect of splashing water; the emperor will not be able to see the emperor after he has passed and become a horse. Therefore, must master the exact method of taking this drug in order to achieve the best effect of lowering sugar. Because the main place of action of these drugs is in the intestine, the absorption of carbohydrates is inhibited in the intestine, so after taking it, gastrointestinal adverse reactions such as abdominal distension, hyperactive intestinal sounds and increased exhaustion are common, so it is necessary to start taking small doses and gradually increase them after adaptation. The drug is not very “crisp” when chewed after it has been exposed to air for a long time, so it is usually opened only when it is needed.