Tuberculosis ball is very likely to be due to poor drug compliance, poor drug efficacy or nutritional deficiencies. 1. Poor adherence: patients in the process of taking anti-tuberculosis drugs compliance is relatively poor, eat a meal, do not eat a meal, which leads to tuberculosis foci increase, tuberculosis symptoms are difficult to control. 2. Ineffective medication: patients are infected with drug-resistant tuberculosis bacilli, in which case conventional anti-tuberculosis medication is ineffective and foci are prone to increase in size; 3. Insufficient nutrition: patients do not strengthen the nutritional support treatment in the process of anti-tuberculosis, and their life rules are not good, such as frequent late nights and overwork. In addition, eating some spicy, stimulating, greasy food, resulting in malnutrition, the body’s resistance to further decline, and then the situation of the lesion enlarged. Appearance of tuberculosis ball is very large situation should promptly seek medical treatment, accept the guidance of professional doctors.