According to the cause of small blisters on the soles of the feet (blisters) is very itchy need to be based on the cause of the selection of drugs, the causes mainly include contact dermatitis, athlete’s foot, eczema and so on. 1. contact dermatitis: foot skin contact with irritating substances or allergic substances caused by inflammatory reaction, in the clinic will be manifested in its small blisters, redness, swelling, itching and other clinical symptoms, can be through the loratadine tablets, ibastine tablets and other drugs for treatment. 2. tinea pedis: tinea pedis is a fungal infection of the foot skin caused by dermatophytes, mostly due to red trichophyton, trichophyton fungus and other etiological factors, in the clinic, mostly manifested as localized skin blisters, itching, dryness and cracking and other symptoms, a lot of the use of clotrimazole cream, biphenylbenzylazole cream, cyclopiazepoxide cream and other medications for treatment. 3. Eczema: abnormal immune function, skin barrier dysfunction, psychosocial factors and other reasons may trigger eczema, mostly manifested in the erythema on the basis of blisters, papules and other symptoms, accompanied by obvious itching, and more than the use of tacrolimus ointment, pimecrolimus cream, hydrocortisone and other medications for treatment. It is recommended to go to the hospital for examination, to clarify the cause of the disease in time to follow the doctor’s instructions for symptomatic treatment.