In general, alcohol should not be consumed while taking the drug, and patients are advised to stop taking the drug for 12 hours before drinking in moderation. Ibuprofen is a non-steroidal analgesic, which can take effect in about 30 minutes after taking the drug, and the blood concentration in the body reaches its peak in about 1 hour. The common adverse effects of ibuprofen are irritation of the gastrointestinal tract, mucosal bleeding and peptic ulcers. Drinking alcohol when ibuprofen is not fully metabolized will not only occur enzymatically in the blood, accelerating drug metabolism and reducing drug efficacy, but may also aggravate gastrointestinal symptoms and increase the risk of gastrointestinal bleeding. Usually, in clinical practice, it is recommended to stop taking ibuprofen for 12 hours before drinking alcohol to ensure the safety of patients. In addition, patients using ibuprofen should also be aware that this drug should not be used for a long time or in large quantities, and should be used reasonably according to symptoms under the guidance of a doctor.