Benidipine is not a substitute for amlodipine, and there are differences in symptoms between the two at different dosages, so replacement of the drug needs to be in accordance with the doctor’s instructions. Amlodipine is a long-acting calcium channel blocker, and its blockage of L-type calcium channels can only block blood vessels. Benidipine is a membrane-controlled long-acting antihypertensive drug, which can block L-type, N-type and T-type calcium channels, and can act on glomerular arteries, sympathetic nerve endings and blood vessels. From the perspective of antihypertensive effect, amlodipine has relatively good antihypertensive effect. For the treatment of variant angina pectoris, benidipine is superior to amlodipine. According to the Chinese Expert Consensus on the Diagnosis and Treatment of Coronary Artery Spasm Syndrome, benidipine is suitable for the treatment of all types of coronary artery spasm angina pectoris, and its clinical efficacy is better than that of diltiazem and amlodipine. Although there are some differences between the two drugs, but the adverse effects of the two drugs are not very different, both can induce certain headache, swelling and other symptoms. To summarize, Benidipine and Amlodipine have their own advantages and focus, should not replace Amlodipine with Benidipine, if the patient’s condition requires, can be replaced in accordance with the doctor’s instructions.