Tretinoin Nasal Spray has been running nose after spraying is not normal, indicating that the treatment is not right or the treatment effect is not satisfactory. Runny nose is caused by upper respiratory tract infection, allergic rhinitis, sinusitis and other diseases, need to apply antiviral drugs, aminocrystalline capsules, nasal decongestant, antibiotics and other drugs for the cause of the treatment. Tretinoin Nasal Spray is mainly used in the treatment of allergic rhinitis, vasomotor rhinitis and symptomatic treatment of sinusitis. If the runny nose is caused by upper respiratory tract infection, patients need to follow the doctor’s instructions to apply antiviral drugs, such as ribavirin, oseltamivir, etc.; as well as cold and flu medicines, such as aminocarbamate capsules, aminophenolamine natriuretica capsules. At this point in time, the use of tretinoin nasal spray may not be the right remedy, so the symptoms will persist. If the runny nose is caused by sinusitis, patients may also need to combine the use of intranasal decongestants such as furosemide drops and hydroxymetazoline drops; antibiotic medications such as cefuroxime and amoxicillin; and combined nasal rinses when using Trimethoprim Nasal Spray. To summarize, patients with runny nose need to go to the hospital, improve the examination, and follow the doctor’s instructions for medication and treatment.