Entecavir tablets can be taken at any point in the 24-hour period, but it is not required that the daily dosing time must be the same, as long as the difference in the daily dosing time does not exceed 3-4 hours. For example, if it is taken every morning at about 8:00 a.m., take it on the second day at no more than 12:00 p.m. The short time difference between daily doses can avoid excessive fluctuations in drug concentration and maintain an effective and stable blood concentration. And entecavir must be taken to ensure that it is fasting, that is, to be separated from food for 2 hours, that is, before and after taking entecavir 2 hours can not eat anything, in order to ensure that it is a fasting state, so that the absorption and utilization of the drug will reach the best.