The lubricant itself is generally harmless to the human body, but if it is used for a long time, it may cause certain effects on the body, such as reproductive system infections, bacterial flora imbalance and so on. 1. Reproductive system infections: long-term use of lubricants during sex may lead to reproductive system infections, such as periapical glans, vaginitis, cervicitis and so on. 2. Bacterial dysbiosis: long-term use of lubricants will make the patient’s vaginal self-purification ability to decline, thus affecting the vaginal pH, which will lead to vaginal dysbiosis, may lead to gynecological diseases. Lubricants are mainly used to help lubricate during sex, especially for amenorrhea or older women, due to their own secretions decrease, the vagina is not enough lubrication. For normal women, there is no need to use lubricants, if special circumstances must use lubricants, should choose safe and reliable.