Malignant tenosynovial giant cell tumor in the early stage generally does not need chemotherapy after radical resection, the tumor is larger, the risk of recurrence is big can be postoperative adjuvant chemotherapy. In case of metastasis, chemotherapy is usually the main treatment, and radiotherapy, such as bone metastasis, can be used to relieve bone pain and reduce fracture. Malignant tenosynovial giant cell tumor is mostly seen in the flexor side of finger and wrist joints, and the treatment is mainly based on surgical resection. Since it is easy to recur or metastasize after resection, some patients need postoperative chemotherapy, which can kill the residual cancer cells and reduce the recurrence and metastasis of the tumor. Malignant giant cell tumor of tendon sheath usually leads to local pain, as well as symptoms of dysfunction, it is recommended that patients should be treated by surgical resection in time, and after metastasis occurs, systemic radiotherapy is needed. It is suggested that patients should pay attention to the protection of the affected limbs in their daily life, and the functional exercise should be gradual and orderly, and the diet should be nutritionally balanced, and proper rest should be taken to avoid exertion.